A recent JAMA Surgery comparison of bariatric surgery and GLP-1 receptor agonists highlights why long-term treatment selection matters
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However, Wegovy uses semaglutide, which has been studied for many years
GLP-1 receptor agonists have been shown in multiple studies to exert anti-inflammatory effects, including inhibition of monocyte chemotaxis, suppression of macrophage inflammatory responses, and AMPK-mediated downregulation of the NF-B signaling pathway, thereby reducing systemic inflammation (36)
She said some studies have suggested musculoskeletal benefits with GLP-1 drugs and that she often sees improvements in joint pain among patients who lose weight on the medications