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While maintaining appropriate levels of iron is vital for regular physiological activities, excessive accumulation can cause cellular ferroptosis ( Iron metabolism is mainly regulated by substances secreted by the liver such as Transferrin (TF), Transferrin receptor (TFR), Ferritin and Hepcidin

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The IR in adipose tissue is a well-known experimental model which has been exploited to clarify the different mechanisms involved in both age-related and obesity-induced IR in rodents