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doi: 10.1016/j.leukres.2012.03.027 104 HowardSCMcCormickJPuiCHBuddingtonRKHarveyRD

Yet, the startling reality is that metabolic and nutritional factors, many of which are modifiable, are now recognized as primary drivers of its pathogenesis, contributing to a global burden that afflicts over 300 million people (1)

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Chronic Inflammation: Ongoing inflammation within the body can trigger increased NAD+ consumption by enzymes involved in the inflammatory response, leading to a decline in overall levels

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