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[10] Diseases affected by IGF [edit] Studies of recent interest show that the Insulin/IGF axis play an important role in aging

Pathol Res Pract (2017) 213(6):62633

The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference

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Both substances are generally recognized as safe at typical supplementation doses, and they do not compete for the same metabolic pathways in a way that would cause dangerous interactions