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GLP1R agonists increase heart rate and might not be beneficial in individuals with severe left ventricular dysfunction, reduced ejection fraction and/or a history of repeated hospitalization for heart failure

Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus

In the CNS, endogenous GLP-1 acts primarily through vagal afferent signaling, transmitting information from the gastrointestinal tract to the brainstem [123, 124]

For patients at JosephCareRX, a good candidate for GLP-1 weight loss medications is typically an adult with a body mass index (BMI) of 30 or higher

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2l) but did not affect insulin secretion (Fig