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Selenium toxicity can be a problem, especially for animals living in or around a body of water in an area with high soil selenium levels

PGC-1 coactiva mltiples factores de transcripcin incluyendo los receptores activados por proliferadores de peroxisomas, particularmente PPAR que regula genes de la beta-oxidacin, los factores respiratorios nucleares NRF-1 y NRF-2 que regulan genes de la cadena de transporte de electrones, y el receptor relacionado con estrgeno ERR

However, symptoms are far more likely to be related to underlying conditions that cause B12 elevationsuch as liver disease, kidney dysfunction, or haematological disordersrather than the elevated B12 itself