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Coronal T2-weighted (T2W) MRI scans (2D TurboRAGE) of the whole brain were performed with a vertical-bore 9.4 T Bruker AVANCE 400WB imaging spectrometer with a 250 mTm 1 actively shielded imaging gradient insert (Bruker BioSpin, Billerica, MA) controlled by Paravision software

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[22] The injections are usually given in a clinic setting, but in some cases patients may be taught to self-administer at home under medical guidance

In some cases, humans develop a response to as little as 5 EU/kg of body weight