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During the phase 3 trial of tirzepatide, 6.6% of patients discontinued the medication due to side effects [114]

These side effects are usually mild and temporary

View this as one component of broader lifestyle efforts

Choosing between tirzepatide and semaglutide depends on your goals, tolerability, and coverage landscape

Cagrilintide is a newer long-acting amylin analogue - in a phase 2 trial, once weekly cagrilintide resulted in a dose-dependent WL between 6 and 10.8% compared to 9% with liraglutide 3 mg and 3% with placebo [87]

For patients with significant insulin resistance, type 2 diabetes, or metabolic syndrome, the dual-action mechanism often delivers noticeably stronger results