When you eat, the nutrients from your food (glucose, fatty acids, and dietary fiber) stimulate the release of GLP-1 hormone in your gut
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In landmark trials, semaglutide demonstrated substantial efficacy in promoting weight loss, with a safety profile consistent with its use in diabetes
Currently, there are several GLP-1 RA medications delivered by injection, which are sold under various brand names, though availability and licensing vary significantly by country (Table 1)
When semaglutide is combined with nutritional guidance, physical activity, and follow-up care, many patients achieve progressive weight changes and then focus on maintenancesometimes using lower maintenance doses alongside continued healthy eating and activity habits to help preserve their results