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Interestingly, in xenograft model, Polyphyllin III, a major saponin extracted from Paris polyphylla rhizomes, which induces Kruppel Like Factor 4-mediated protective upregulation of SLC7A11, in combination with the System X c inhibitor SAS, may have a co-induction in MDA-MB-231 breast cancer cells by enhancing intracellular lipid peroxidation and ferroptosis (Zhou Y