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We report discovery of a G protein-coupled receptor (GPCR) ligand that stabilizes an active state conformation by cooperatively binding both the receptor and orthosteric ligand, thereby acting as a molecular glue

Most cases can be managed conservatively without discontinuing the medication

Greater HbA 1c and body weight reductions were seen across background medication subgroups with oral semaglutide (changes from baseline: 1.0 to 1.5% and 2.2 to 5.0 kg, respectively) than with comparators (except for similar HbA 1c reductions vs liraglutide)

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Healthcare providers can assess whether symptoms represent normal adjustment to semaglutide or indicate a need for dose modification, temporary discontinuation, or investigation for alternative diagnoses