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Al-Aly thinks that might be an underestimate because even though the study followed huge numbers of people, it covered only about four years, so they might have seen more Alzheimers cases if the study had gone on for longer, which might have translated to a larger benefit

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doi: 10.1007/s13679-024-00585-w 151 BettgeKKahleMAbd El AzizMSMeierJJNauckMA

Furthermore, even after including treatment discontinuation as an additional censoring criterion during the follow-up, Cox regression analysis continued to reveal a significant and substantial risk of major CI associated with DPP-4i exposure

Meeran, K