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The glutathione moieties of GSSR and GSH have to interact with different protein areas as a result of the S N 2 geometry of both half-reactions of the ping pong bi-bi mechanism (Fig

Intravenous administration allows glutathione to bypass the digestive system, leading to higher bioavailability and more effective increases in glutathione levels compared to oral supplements

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Due to non-selective receptor activity, it also affects multiple physiological signaling systems

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