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Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]

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While the future direction of demonstration waivers is uncertain, recent actions from the Trump administration could signal efforts to curtail waivers related to social determinants of health and to limit waiver financing tools and flexibility

doi: 10.1093/oxfordjournals.aje.a113631 58 SaidM-EGoldsteinHKorraAEl-KashlanK