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Gln deprivation can enhance the sensitivity of A2780cis cells to cisplatin by promoting the methylation of the GS promoter, inhibiting GS synthesis, and downregulating intracellular GSH levels ( Furthermore, Gln metabolism can also exert epigenetic influences on tumor resistance

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In addition, NRF2 regulates genes involved in iron metabolism such as ferritin ( FTL/FTH1 ) and ferroportin ( SLC40A1 ) [43]

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