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However, by lacking the extended peptide sequences of the parent compound, TB-500 does not reproduce the full range of thymosin beta-4s regulatory capacity

What does the article say happens after week 20

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Maturation skews macrophage polarization from M1 to M2 (interleukin-4 [IL-4], interleukin-10 [IL-10], IL-12, Arginase 1 [Arg-1]

lixisenatide was historically part of the class but is discontinued in the United States

Although pharmacological data make it very clear that GLP-1 regulates insulin secretion, genetic data suggest that the system is more complex than a simple endocrine model of insulin regulation