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Elevated cAMP activates protein kinase A (PKA), which phosphorylates and activates hormone-sensitive lipase (HSL) and other lipases responsible for hydrolyzing triglycerides

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Apart from zidovudine used in the treatment of HIV infection, antimalarials, oestrogen, ketoconazole, clofazimine, and imatinib may mediate the development of oral mucosal melanin hyperpigmentation [12, 38]

However, the gradual depletion of stores means that deficiency develops insidiously

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