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Vitamin B12 Deficiency Long-term use of metformin can interfere with vitamin B12 absorption in the stomach and small intestine, leading to a deficiency in about 6% to 30% of users - especially those on higher doses or taking it for four years or longer

"Recognizing Degradation in Injectable Medications: A Guide for Healthcare Professionals and Patients." Pharmacy Today, 29(6), 45-52.

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