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En los estudios AMIGO (Diabetes Management for Improving Glucose Outcomes), que fueron 3 ensayos aleatorizados, triple ciego, controlados con placebo y multicntricos de 30 semanas que tenan un diseo similar, se evalu el impacto del tratamiento con exenatida 2 veces al da (en dosis de 5 y 10g) en el control glucmico en los pacientes con DM2 con mal control metablico que estuvieran en tratamiento con metformina y/o sulfonilurea1315

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