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You should contact your GP or diabetes specialist nurse if you experience: Persistent low mood lasting more than two weeks Significant anxiety that interferes with daily activities Loss of interest in activities you previously enjoyed Changes in sleep or appetite beyond those explained by gastrointestinal side effects Difficulty concentrating or making decisions Feelings of hopelessness or worthlessness Seek urgent medical attention by contacting your GP, calling NHS 111, or attending A&E if you experience: Thoughts of self-harm or suicide Severe depression that prevents you from functioning Panic attacks or severe anxiety episodes Any mental health crisis Call 999 or go to A&E immediately if you are at immediate risk of harm