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If there is any doubt about the integrity of a solution whether due to appearance, storage history, or uncertainty about the beyond-use date the safest course of action is always to discard it and seek advice from the trial team, supervising clinician, or a registered pharmacist before proceeding
Hong, S., et al
These nonseroconverters include people on B-cell-depleting therapy or people with inborn errors of immunity, as these individuals are typically more susceptible to prolonged infection and higher rates of progression to severe disease [36, 37]
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The optimal protocol is to inject first thing in the morning, after an overnight fast of at least 8 hours
(2) Chang CH, Tsai WC, Hsu YH, Pang JH
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