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By measuring the ratio of heavy isotope-labelled peptides in urine samples using liquid chromatography (LC)-MS in multiple reaction monitoring (MRM) mode, we observed significantly higher Ggt1 levels in the OVX rats than in the control rats (Figure 3C, peptide determination results are shown in Supplementary Tables S9)

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MRI-derived iron-corrected T1 (cT1) has been validated for distinguishing at-risk MASH with an AUROC of 0.78 in biopsy-confirmed MASLD patients

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