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Lipid hydroperoxides, generated primarily through the activity of lipoxygenases (LOXs), are key mediators of cellular dysfunction and death ( 2.1.3 Antioxidant system 2.1.3.1 System Xc-/GSH/GPX4 axis The cystine/glutamate antiporter (System Xc-), glutathione (GSH), and glutathione peroxidase 4 (GPX4) form a critical antioxidant axis that plays a central role in regulating ferroptosis

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