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Practical factorssuch as insurance coverage, approved indication (type 2 diabetes vs obesity), drug availability, previous side effects, and co-existing health conditionsusually matter more than subtle mechanistic differences when deciding which medication to use and how aggressively to dose it

Fu H, Gao W, Tang Y, Liu X, Wang M, Zhang J, et al

R 4-OH catechol estrogens that are not methylated by COMT can be oxidized to quinones that generate reactive oxygen species and form DNA adducts, a mechanism implicated in estrogen-dependent cancers

Second, the canonical TLR4 pathway is now shown to be a crucial driver of the signals linking LPS to the stimulation of GLP-1 secretion

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Both require provider prescription