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Medications like methotrexate, TNF-alpha inhibitors, and other biologics often show decreased efficacy in patients with higher body weight

Previous study revealed that HDAC6 promoted cell migration by deacetylated cytoplasmic proteins such as -tubulin [45]

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While generally safe, some side effects can include mild nausea, dizziness, or allergic reactions

GPER also modulates lipid metabolism and the energy balance, suggesting its therapeutic potential for metabolic disorders [79]

The most common bodys natural response to the medication is a gastrointestinal issue, such as nausea, vomiting, diarrhea, or constipation