The primary theoretical concern is that sustained NAD+ elevation through chronic NNMT inhibition could activate pathways (PARP, SIRT1) that have context-dependent roles in cancer biology NAD+ supports DNA repair and cellular longevity, but also fuels rapidly dividing cells
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None of that makes them useless
Specifically, vitamin B12 plays a crucial role in converting food into energy, while other vitamins in the shots can also help improve immune function, cognitive performance, and overall well-being
The targeted action of 5-Amino-1MQ on NNMT also suggests potential benefits in addressing age-related metabolic decline and obesity-related disorders (3)