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Its regulation affects sleep continuity, REM sleep patterns, and has implications for the therapeutic mechanisms of antidepressants, highlighting its importance in both the manifestation of insomnia and its potential as a target for preventing depression linked to sleep disturbances ( Dopamine plays a crucial role in the transition from nonrapid eye movement (NREM) sleep to rapid eye movement (REM) sleep through a transient increase in the basolateral amygdala (BLA), acting on D2 dopamine receptors to initiate the NREM-to-REM shift

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Numerous NADs have transitioned from bench to bedside and have successfully been approved for clinical trials (Fig

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