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Iwasaki Y, Sendo M, Dezaki K, Hira T, Sato T, Nakata M, Goswami CC, Aoki R, Arai T, Kumari P, Hayakawa M, Masuda C, Okada T, Hara H, Drucker DJ, Yamada Y, Tokuda M, Yada T

Diabetologia.1986 Jan;29(1):46-52

The body weight-lowering effects of multi-agonists are primarily due to their anorectic actions As multi-agonist therapies elicited a marked reduction in body weight during the first week of treatment, we assessed the putative mechanisms associated with such weight loss

Navigating Your Retatrutide Dose and Administration Effective weight loss medication requires precision

Compare the stated molecular weight on the mass spec report to the theoretical molecular weight of retatrutide (approximately 4113.58 Da for the free base)

The researchers also observed that 532 participants with BMI 35 at week 0, who had tolerated their assigned dose of medication, were then escalated to the maximum tolerated dose (9mg or 12mg) for a further 24 weeks