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The degeneration of dopaminergic neurons is the main pathophysiological attribute of PD, which is accompanied by a decrease in dopamine secretion (2), and over time, motor (tremor, muscle rigidity, slowness of movement, and imbalance) and non-motor (postural hypotension, depression, sleep disorders, hallucinations, fatigue, and pain) symptoms appear (3)

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A meta-analysis of clinical trials found that the use of pioglitazone, a TZD, was associated with significant improvements in depressive symptoms

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doi: 10.1016/0006-291X(74)90445-8

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