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Both affect GLP-1 receptors, but tirzepatide also targets GIP receptors, creating a dual-action effect

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5.2 Acute Pancreatitis Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including liraglutide [see Adverse Reactions (6)]

Among other metabolites that exhibited significant changes in the metabolomic analysis, spermidine (ratio: 1.3), a polyamine having strong anti-oxidant activity, acts as an intrinsic free radical scavenger

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