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Clinical Studies Clinical Studies in Adults The effect of phentermine and topiramate extended-release on weight loss in conjunction with reduced caloric intake and increased physical activity was studied in two randomized, double-blind, placebo-controlled studies in patients with obesity (Study 1) and patients with obesity or overweight with two or more significant co-morbidities (Study 2)

Although primary BAs are elevated in the stool of both IBS-C and IBS-D patients (Mars et al., 2020), secondary BAs are reduced in the latter group ( de novo synthesis (Mars et al., 2020)

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