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ROS also stabilizes MAPK activation indirectly by inactivating MAPK phosphatases (MKPs): Oxidation of catalytic cysteines prevents their dephosphorylation activity [71], and oxidative stress can induce MKP degradation [72]

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Mahmoodzadeh S, Dworatzek E (2019) The role of 17-estradiol and estrogen receptors in regulation of Ca2 + channels and mitochondrial function in cardiomyocytes

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