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Similar to DON, acivicin and azaserine are also glutamine analogs that interrupt nucleotide synthesis by inhibiting amidotransferases [110, 116]

Weeks 1 to 4: Foundation Phase Side effects are usually mild or absent during the first four weeks at the 2 mg starting dose

doi: 10.1177/1753495X19847832 96 GarrudTACGiussaniDA

They result from the body adjusting to the medication's effects on gastrointestinal function and appetite regulation

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Rapid weight reduction can signal energy deficit to the hypothalamus, potentially suppressing gonadotropin-releasing hormone (GnRH) pulsatility