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It might mean the dose is no longer sufficient, protein has dropped too low, or stress and sleep have deteriorated enough to override the medication's effects

[15] Always follow dosing instructions and consult your pharmacist if you have questions about appropriate pain relief options

But it can be discouraging if weight loss is slow or hasnt started in the first few weeks

Its currently being studied in a phase 2 trial to test different doses

But that also increases the odds of adverse reactions