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The primary outcome of this study was the first diagnosis of CRC within 15 years from the initial treatment of GLP-1RAs or non-GLP-1RA diabetes medications (insulin, metformin, alpha-glucosidase inhibitors, dipeptidyl-peptidase-4 inhibitors (DPP-4i), sodium-glucose cotransporter-2 inhibitors (SGLT2i), sulfonylureas (SU), and thiazolidinediones (TZD))

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Behavioral changes often improve sleep without the need for medications

The mechanism of action of these drugs, in simple terms, is that they mimic natural gut hormones (such as GLP-1, and in the case of tirzepatide, also GIP) which regulate appetite and satiety