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The comparative effectiveness of an expanded 2-year on-treatment analysis that followed patients who stay on the exposure or comparator therapies for a prolonged time showed concordant results with the 1-year on-treatment analysis (Supplementary Table 25)
These were dose-dependent and mitigated with lower starting doses (e.g., 2 mg vs
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Unlike currently approved weight loss medications, retatrutide works as a triple agonist, meaning it targets three different hormone receptors: GIP, GLP-1, and glucagon receptors