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The medication is a single molecule that targets both incretin receptors, GLP-1r and GIPr

Specifically, the combination of MCT4 inhibition with ferroptosis inducers not only depletes lactate accumulation but also enhances CD8+ T cell infiltration and ferroptosis-driven ICD, thereby synergistically improving checkpoint blockade efficacy (111)

Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury

A diet high in simple carbohydrates, like what's found in processed foods and sugary drinks, fried food, alcohol and high fructose, significantly impacts weight gain