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While malate was thought to contribute to increased ATP production through the TCA cycle, the review emphasized that these pathways have not yet been verified in human models and that more research is needed (Gonzalez and Trexler, Nutrients )

From a pharmacokinetic perspective, NAC may be administered orally, intravenously, or via aerosol and has been well-tolerated at even high dosing (Bavarsad Shahripour et al

At 8:30 am and at 12:00 pm, standardized, savory meals were provided (consisting of 116 g carbohydrates, 60 g fat, 25 g protein, 12 g fiber, and 5.7 g salt, for a total of 1284 kcal)

A small number of people with two variant copies have higher-than-normal homocysteine levels

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