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Statins inhibit hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, a key enzyme in cholesterol synthesis in hepatocytes, resulting in increased LDL receptor activity on these cells and increased clearance of lipoproteins containing apolipoprotein B-100, i.e., LDL and VLDL remnants (including intermediate density lipoprotein IDL) [35, 50]

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