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Both PTGS2 and SAT1 can affect the abundance and distribution of polyunsaturated fatty acids (essential substrates for ferroptosis), thus affecting lipid peroxidation and ferroptosis (Zheng and Conrad, 2020)

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In vitro studies have found that inhibiting the transcriptional activity of Nrf2 can reduce the synthesis of glutathione, thereby causing the apoptosis of IDH1 mutant cancer cells

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