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f ) In vitro ubiquitylation assay as in (a) but performed with the endogenous NMNAT1 substrate to recapitulate its previously reported CTLH E3-dependent regulation

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Using a one-way ANOVA model ( = 0.05, six groups, n = 7 per group equivalent), the observed effect size (Cohens f) was 1.59, corresponding to an value of 0.72

doi: 10.1038/s41589-019-0408-1 149 WortmannMSchneiderMPircherJHellfritschJAichlerMVegiNet al

Remains on Category 2 with no current PCAC referral

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