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So, Tirzepatide dose-dependently reduced voluntary alcohol consumption, prevented binge and relapse-like drinking, Studies have shown reduced alcohol use in patients prescribed GLP-1 agonists

Mechanism of action and physiological action GLP-1 is secreted by L cells in the ileum upon meal stimulation [24]

The RhoA/ROCK pathway plays a significant role in the differentiation of L-cells and other secretory cells by regulating cytoskeleton dynamics and YAP signaling

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Endocrinology (1996) 137(7):296878