Characterization of human glutaredoxin 2 as iron-sulfur protein: A possible role as redox sensor
The clinical application requires understanding both the peptide's mechanisms and appropriate dosing strategies for specific conditions
Specifically, three mitochondrial proteins (GSR, PRDX5, and SOD2) exhibited expression patterns that have not been previously documented in the context of male infertility
Introduction Several studies have concluded that oxidative stress, due to increased production of reactive oxygen species (ROS), for instance, because of infection, can trigger inflammation, although the concept has been considered an oversimplification ( While in the context of oxidative stress GSH acts as an antioxidant ROS scavenger, in the context of redox regulation the couple GSH/GSSG (oxidized GSH) acts as a signaling molecule that regulates protein function via thioldisulfide exchange reactions including protein glutathionylation ( To investigate the role of endogenous GSH in inflammation, whether it acts as an antioxidant or a signaling molecule, we used the mouse macrophage RAW cell line stimulated with lipopolysaccharide (LPS) with and without pretreatment with the GSH synthesis inhibitor buthionine sulfoximine (BSO)
however, the precise mechanisms are still under investigation
(2011) reported some injury symptoms, such as leaf chlorosis, necrosis and stunting in barley seedlings when subjected to Cd (5 M)
