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The copper ion component is essential for lysyl oxidase activity, an enzyme critical for collagen and elastin cross-linking

Additionally, combining treatments with Melanotan can heighten skin sensitivity, raising the chances of irritation or adverse reactions

Its primary limitation is that it uses conventional reduced glutathione rather than a specialized liposomal or S-acetyl form

doi: 10.1038/s41598-018-38216-9 147 ZhangX.ShenD.FangZ.JieZ.QiuX.ZhangC.et al

It also mentions ginger, peppermint tea, and digestive enzymes as offering relief for some patients

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