Methimazole is metabolized through cytochrome P450 (CYP) enzymes35,36 and flavoprotein mixed-function oxidase (FMO).37,38 Methimazole metabolism through CYP450 enzymes gives N-methylthiourea and glyoxal as two major metabolites.36 Nmethylthiourea is further oxidized with FMO enzyme to give sulfinic and sulfenic acid species.38 Glyoxal, is a reactive compound capable of interacting with different intracellular targets, such as proteins.39 Sulfenic acids are high electrophilic species that form irreversible adduct with cellular nucleophilic sites,40 and may have a role in methimazole-induced hepatotoxicity
Turning down the volume in your head could make all the difference in sticking to healthier habits
Bruising and Small Lumps A small bruise is usually the result of the needle nicking a tiny capillary
R., Johansson, E., Fulle, S., Skyggebjerg, R
Davis MC, Green MF, Lee J, Horan WP, Senturk D, Clarke AD et al (2014)
Chemical structure by Henry Jakubowski.
