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There are two main schedules in the published research

Retatrutide is started at a low dose

Notably, at higher doses (such as 12 mg once weekly), mean weight loss exceeding 20% of body weight was observed in adults with obesity over approximately 48 weeks

Research has also described a distinct potency pattern across its receptor targets: Strong GIP receptor activity (around 8.9 higher than native GIP) Moderate GLP-1 receptor activation (about 0.4 relative potency) Modest glucagon receptor activity (about 0.3 relative potency) This balanced profile provides a framework for studying coordinated metabolic responses rather than isolated single-pathway effects