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5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD

Obese rats fed with a high-fat diet weighed more initially (588.7 14.1 g) than rats on a standard chow diet (497.8 15.1 g, p 0.05, n.s.)