These finding is not unexpected since GLP-1 may increase natriuresis through the inhibition of many ion exchangers in the tubules which expression decreases with the progression of CKD and interstitial fibrosis and tubular atrophy 33
A landmark 2021 study in the New England Journal of Medicine showed that participants taking semaglutide for 68 weeks, combined with lifestyle changes, lost an average of nearly 15% of their body weight
It is important to recognize that weight maintenance is a lifelong process, and vigilance is needed to prevent weight regain
On the other hand, there were no significant differences in D2R availability between the obese and non-obese women
Espino J, Macedo M, Lozano G, et al
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