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A patch test is recommended for sensitive skin

A cloudy, clumped, precipitated, or otherwise unsuccessful mixture does not, by itself, establish that the diluent was defective, contaminated, improperly formulated, or unsuitable.

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It can cross the BBB (concentrations in gerbil brain are estimated to approach 0.5 mM after an injection of 150 mg PBN/kg body weight (Yue et al., 1992)

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