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Due to the high reaction specificity and orthogonality of the CuAAC click reaction, this two-component stapling strategy can incorporate crosslinks with different chemical properties and functionalized modifications through double-click reactions involving two side chains with azido functional groups at the i , i + 4, or i + 7 positions and a dialkynyl linker

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The inhibitory effect of Gal-7 on TGF-1-induced apoptosis has been related to the activity of caspase-3 and the induction of Bax, Bcl-2, and PARP

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Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma